The Immunology Time Line
11/08/2013 19:18History of immunology time line
- 1798 Edward Jenner, Smallpox vaccination
- 1862 Ernst Haeckel, Recognition of phagocytosis
- 1877 Paul Erlich, recognition of mast cells
- 1879 Louis Pasteur, Attenuated chicken cholera vaccine development
- 1883 Elie Metchnikoff Cellular theory of vaccination
- 1885 Louis Pasteur, Rabies vaccination development
- 1888 Pierre Roux & Alexandre Yersin, Bacterial toxins
- 1888 George Nuttall, Bactericidal action of blood
- 1891 Robert Koch, Delayed type hypersensitivity
- 1894 Richard Pfeiffer, Bacteriolysis
- 1895 Jules Bordet, Complement and antibody activity in bacteriolysis
- 1900 Paul Erlich, Antibody formation theory
- 1901 Karl Landsteiner, A, B and O blood groupings
- 1901-8 Carl Jensen & Leo Loeb, Transplantable tumors
- 1902 Paul Portier & Charles Richet, Anaphylaxis
- 1903 Almroth Wright & Stewart Douglas, Opsonization reactions
- 1906 Clemens von Pirquet, coined the word allergy
- 1907 Svante Arrhenius, coined the term immunochemistry
- 1910 Emil von Dungern, & Ludwik Hirszfeld, Inheritance of ABO blood groups
- 1910 Peyton Rous, Viral immunology theory
- 1914 Clarence Little, Genetics theory of tumor transplantation
- 1915-20 Leonell Strong & Clarence Little, Inbred mouse strains
- 1917 Karl Landsteiner, Haptens
- 1921 Carl Prausnitz & Heinz Kustner, Cutaneous reactions
- 1924 L Aschoff, Reticuloendothelial system
- 1926 Lloyd Felton & GH Bailey, Isolation of pure antibody preparation
- 1934-8 John Marrack, Antigen-antibody binding hypothesis
- 1936 Peter Gorer, Identification of the H-2 antigen in mice
- 1940 Karl Lansteiner & Alexander Weiner, Identification of the Rh antigens
- 1941 Albert Coons, Immunofluorescence technique
- 1942 Jules Freund & Katherine McDermott, Adjuvants
- 1942 Karl Landsteiner & Merill Chase, Cellular transfer of sensitivity in guinea pigs (anaphylaxis)
- 1944 Peter Medwar, Immunological hypothesis of allograft rejection
- 1948 Astrid Fagraeus, Demonstration of antibody production in plasma B cells
- 1948 George Snell, Congenic mouse lines
- 1949 Macfarlane Burnet & Frank Fenner, Immunological tolerance hypothesis
- 1950 Richard Gershon and K Kondo, Discovery of suppressor T cells
- 1952 Ogden and Bruton, discovery of agammagobulinemia (antibody immunodeficiency)
- 1953 Morton Simonsen and WJ Dempster, Graft-versus-host reaction
- 1953 James Riley & Geoffrey West, Discovery of histamine in mast cells
- 1953 Rupert Billingham, Leslie Brent, Peter Medwar, & Milan Hasek, Immunological tolerance hypothesis
- 1955-1959 Niels Jerne, David Talmage, Macfarlane Burnet, Clonal selection theory
- 1957 Ernest Witebsky et al., Induction of autoimmunity in animals
- 1957 Alick Isaacs & Jean Lindemann, Discovery of interferon (cytokine)
- 1958-62 Jean Dausset et al., Human leukocyte antigens
- 1959-62 Rodney Porter et al., Discovery of antibody structure
- 1959 James Gowans, Lymphocyte circulation
- 1961-62 Jaques Miller et al., Discovery of thymus involvement in cellular immunity
- 1961-62 Noel Warner et al., Distinction of cellular and humoral immune responses
- 1963 Jaques Oudin et al., antibody idiotypes
- 1964-8 Anthony Davis et al., T and B cell cooperation in immune response
- 1965 Thomas Tomasi et al., Secretory immunoglobulin antibodies
- 1967 Kimishige Ishizaka et al., Identification of IgE as the reaginic antibody
- 1971 Donald Bailey, Recombinent inbred mouse strains
- 1974 Rolf Zinkernagel & Peter Doherty, MHC restriction
- 1975 Kohler and Milstein, Monoclonal antibodies used in genetic analysis
- 1984 Robert Good, Failed treatment of severe combined immunodeficiency (SCID, David the bubble boy) by bone marrow grafting.
- 1985 Tonegawa, Hood et al., Identification of immunoglobulin genes
- 1985-7 Leroy Hood et al., Identification of genes for the T cell receptor
- 1990 Yamamoto et al., Molecular differences between the genes for blood groups O and A and between those for A and B
- 1990 NIH team, Gene therapy for SCID using cultured T cells.
- 1993 NIH team, Treatment of SCID using genetically altered umbilical cord cells.
- 1985-onwards Rapid identification of genes for immune cells, antibodies, cytokines and other immunological structures.
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