Following is the review based on research article “Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells" (search result from www.nature.com)

Link to the original site:

https://www.nature.com/ni/journal/v14/n6/full/ni.2584.html

Abstract

Type 2 immunity is critical for defense against cutaneous infections but also underlies the development of allergic skin diseases. We report the identification in normal mouse dermis of an abundant, phenotypically unique group 2 innate lymphoid cell (ILC2) subset that depended on interleukin 7 (IL-7) and constitutively produced IL-13. Intravital multiphoton microscopy showed that dermal ILC2 cells specifically interacted with mast cells, whose function was suppressed by IL-13. Treatment of mice deficient in recombination-activating gene 1 (Rag1^−/−) with IL-2 resulted in the population expansion of activated, IL-5-producing dermal ILC2 cells, which led to spontaneous dermatitis characterized by eosinophil infiltrates and activated mast cells. Our data show that ILC2 cells have both pro- and anti-inflammatory properties and identify a previously unknown interactive pathway between two innate populations of cells of the immune system linked to type 2 immunity and allergic diseases.

Reprinted by permission from Macmillan Publishers Ltd: [Nature Immunology]14, 564–573,(2013), copyright (Published online 

21 April 2013)

Reference:

Ben Roediger et al. (2013). Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells, Nature Immunology14,564–573.

Review: (review stated directly from ww.asianscientist.com)

Researchers have discovered a new type of immune cell in our skin that could be linked to eczema and other allergies.

The findings, published this week in the journal Nature Immunology, was the result of a collaboration among researchers from the University of Sydney’s affiliated Centenary Institute and colleagues in New Zealand, the UK, and the US.

The new cell type is part of a family known as group 2 innate lymphoid cells (ILC2), discovered years ago in the laboratory of Professor Wolfgang Weninger, which had developed techniques for marking different cells of the immune system and tracking them live under the microscope.